Recent Publications
- Ken Mautner, Michael Gottschalk, Scott D. Boden, Alison Akard, Won C. Bae, Lora Black, Blake Boggess, Paramita Chatterjee, Christine B. Chung, Kirk A. Easley, Greg Gibson, Josh Hackel, Katie Jensen, Linda Kippner, Chad Kurtenbach, Joanne Kurtzberg, R. Amadeus Mason, Benjamin Noonan, Krishnendu Roy, Verle Valentine, Carolyn Yeago & Hicham Drissi. Cell-based Versus Corticosteroid Injections for Knee Pain in Osteoarthritis: A Randomized Phase 3 Trial. Nature Medicine. 2023. https://doi.org/10.1038/s41591-023-02632-w
- Wang, B., Bowles-Welch, A. C., Yeago, C., Roy, K., J. Adv. Manuf. Process. 2022, 4(1), e10106. https://doi.org/10.1002/amp2.10106
- Stevens HY, Bowles AC, Yeago C, and Roy K (2020) Molecular Crosstalk Between Macrophages and Mesenchymal Stromal Cells. Front. Cell Dev. Biol. 8:600160. doi: 10.3389/fcell.2020.600160
- Medrano-Trochez, C., Chatterjee, P., Pradhan, P. et al. Single-cell RNA-seq of out-of-thaw mesenchymal stromal cells shows tissue-of-origin differences and inter-donor cell-cycle variations. Stem Cell Res Ther 12, 565 (2021). https://doi.org/10.1186/s13287-021-02627-9
- Keenum MC, Chatterjee P, Atalis A, Pandey B, Jimenez A, Roy K. Single-cell epitope-transcriptomics reveal lung stromal and immune cell response kinetics to nanoparticle-delivered RIG-I and TLR4 agonists. Biomaterials. 2023 Jun;297:122097. doi: 10.1016/j.biomaterials.2023.122097.
- Jimenez AC, Heist CA, Navaei M, Yeago C, Roy K. Longitudinal two-dimensional gas chromatography mass spectrometry as a non-destructive at-line monitoring tool during cell manufacturing identifies volatile features correlative to cell product quality. Cytotherapy. 2022 Nov;24(11):1136-1147. doi: 10.1016/j.jcyt.2022.06.001.
- Culberson AL, Bowles-Welch AC, Wang B, Kottke PA, Jimenez AC, Roy K, Fedorov AG. Early detection and metabolic pathway identification of T cell activation by in-process intracellular mass spectrometry. Cytotherapy. 2023 Sep;25(9):1006-1015. doi: 10.1016/j.jcyt.2023.03.010.
- Casteleiro Costa P, Wang B, Filan C, Bowles-Welch A, Yeago C, Roy K, Robles FE. Functional imaging with dynamic quantitative oblique back-illumination microscopy. J Biomed Opt. 2022 Jun;27(6):066502. doi: 10.1117/1.JBO.27.6.066502.
- Bowles-Welch AC, Jimenez AC, Stevens HY, Frey Rubio DA, Kippner LE, Yeago C, Roy K. Mesenchymal stromal cells for bone trauma, defects, and disease: Considerations for manufacturing, clinical translation, and effective treatments. Bone Rep. 2023 Jan 20;18:101656. doi: 10.1016/j.bonr.2023.101656.
- Casey E Vantucci, Tyler Guyer, Kelly Leguineche, Paramita Chatterjee, Angela Lin et al. Systemic Immune Modulation Alters Local Bone Regeneration in a Delayed Treatment Composite Model of Non-Union Extremity Trauma. Front. Surg., 07 July 2022, Sec. Reconstructive and Plastic Surgery. https://doi.org/10.3389/ fsurg.2022.934773
- Culberson AL, Chilmonczyk MA, Kottke PA, Bowles-Welch AC, Ghosha D, Federov AG. (2021) Sample-to-Analysis Platform for Rapid Intracellular Mass Spectrometry. Lab on a Chip, 21(23):4696-4706. doi: 10.1039/d1lc00884f PMID: 34751694
- Van Grouw A, Colonna MB, Maughon TS, Shen X, Larey AM, Moore SG, Yeago C, Fernandez FM, Edison AS, Stice SL, Marklein RA, Bowles-Welch AC. Development of a Robust Consensus Modeling Approach for Identifying Cellular and Media Metabolites Predictive of Mesenchymal Stromal Cell Potency. Stem Cells, 41(8):792-808. doi: 10.1093/stmcls/sxad039 PMID: 37279550
- Doron G, Klontzas ME, Mantalaris A, Guldberg RE, Temenoff JS. Multiomics characterization of mesenchymal stromal cells cultured in monolayer and as aggregates. Biotechnol Bioeng. 2020 Jun;117(6):1761-1778. doi: 10.1002/bit.27317.
In the News
Georgia Tech to Build New $23 Million Research Center
Georgia Research Alliance and Georgia Tech sources also provided funding for a total investment of $23 million. The center also plans to seek funding from federal agencies, clinical research organizations and other sources.
New Cell Manufacturing Research Facility will Change Approaches to Disease Therapies
The vision of making affordable, high-quality cell-based therapies available to hundreds of thousands of patients worldwide moved closer to reality June 6 with the dedication of a new cell…
Stem Cell Factory Opens Door for Trials of Personalized Diabetes Treatment
In a step that could lead to a new diabetes treatment, several Boston-area hospitals have teamed up with the Harvard Stem Cell Institute and biotech Semma Therapeutics to make personalized cell-based therapies and organize clinical trials.
New Institute Aims to Help Bring Cell-based Medicines to Market
December 22, 2016
The Georgia Institute of Technology will play a key role in a new federally backed initiative to advance medications made from cells, such as vaccines…
Research Center Will Focus on Consistent Manufacturing Methods for Cell-Based Therapies
The work of the new Marcus Center for Therapeutic Cell Characterization and Manufacturing (MC3M) is expected to provide standardized production and quality testing of these living cells, similar to that which already exists for drug-based pharmaceuticals.
Inside the Effort to Bring Life-Saving Cell Therapies to the Masses
Doctors knew long before Owen Webb was born that they were racing against the clock to save his life.
New Georgia Tech Research Center Launched to Manufacture Living Cells for Cell-Based Therapies
A $15.7 million grant from the Atlanta-based Marcus Foundation has helped launch a new Georgia Institute of Technology research center that will develop processes and techniques for ensuring the consistent, low-cost, large-scale manufacture of…
Roy Discusses Cell Manufacturing at Georgia Tech
In this age of rapidly changing technology and global challenges, the question has become, “What’s next…
Consortium develops national roadmap for advanced cell manufacturing, showing the way to cell-based therapeutics.
Roy’s Roadmap Leads to the Vatican
Krishnendu Roy scanned the room, taking note of the people all around him in the Vatican, and thought, “what the heck am I doing here?”
Scaling Up Cell-Based Therapies
Georgia Tech, GRA and industry partners charting a path to large-scale manufacturing of cell-based therapeutics.
Roadmap for Advanced Cell Manufacturing /v n nvcnb Path to Cell-Based Therapeutics
An industry-driven consortium has developed a national roadmap designed to chart the path to large-scale manufacturing of cell-based therapeutics for use in a broad range of illnesses including…
Center Will Develop Consistent Manufacturing Processes for Cell-based Therapies
A $15.7 million grant from the Atlanta-based Marcus Foundation has helped launch a new Georgia Institute of Technology research center that will develop processes and techniques for ensuring the…